Who proposed the One Gene–One Enzyme hypothesis?
Analysis & Theory
Beadle and Tatum proposed the hypothesis after experiments on Neurospora crassa.
Which organism was used in the One Gene–One Enzyme experiment?
B
Saccharomyces cerevisiae
D
Drosophila melanogaster
Analysis & Theory
Neurospora crassa (a red bread mold) was used in the famous genetic experiments.
The One Gene–One Enzyme hypothesis links:
B
A gene to a polypeptide
Analysis & Theory
The hypothesis originally suggested that each gene controls the production of a specific enzyme.
Which type of mutation was used by Beadle and Tatum to study gene function?
Analysis & Theory
They used nutritional mutants that could not synthesize specific amino acids.
The One Gene–One Enzyme hypothesis was later modified to:
C
One Gene–One Polypeptide
Analysis & Theory
It was updated to 'One Gene–One Polypeptide' as some proteins are composed of multiple polypeptides.
What was the significance of Beadle and Tatum's experiments?
A
They discovered DNA structure
B
They showed genes carry hereditary information
C
They established a link between genes and enzymes
D
They identified the genetic code
Analysis & Theory
Their experiments showed that genes control specific enzymes, laying groundwork for molecular biology.
Which of the following statements is TRUE based on the One Gene–One Enzyme hypothesis?
A
All enzymes are made of DNA
B
One enzyme controls multiple genes
C
Each gene codes for one specific enzyme
D
All genes code for lipids
Analysis & Theory
Each gene is responsible for producing one specific enzyme.
What was a limitation of the original One Gene–One Enzyme hypothesis?
C
It did not apply to multicellular organisms
D
It did not account for multi-subunit proteins
Analysis & Theory
Many proteins are composed of multiple polypeptides encoded by different genes.
What technique helped Beadle and Tatum determine gene function?
A
Protein electrophoresis
C
Mutagenesis and minimal media analysis
D
Gel filtration chromatography
Analysis & Theory
They used mutagenesis and analyzed growth on minimal media to identify gene-enzyme relationships.
What modern molecular biology concept evolved from the One Gene–One Enzyme hypothesis?
A
Central dogma of molecular biology
C
Complementary base pairing
D
Semiconservative replication
Analysis & Theory
It laid the foundation for the central dogma: DNA → RNA → Protein.